Letrozole side effect CTS

Albizia
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After a quadrantectomy because of ILC I got hormone therapy with Letrozole. A few months later both my hands began to tingle and feel numb. Especially in the night. CTS was diagnosed and I could apply for an operation. Whereas my mother suffered from CTS I supposed that the cause might be genetic but later I learned that rather a lot of women suffer from CTS as a side effect of Letrozole. However only on websites which deal with cancer and never on websites which deal with CTS, which wonders me.
I still really hesitate about an operation and hope I can manage without it. At first splints helped me through the night and now I use the adhesive plaster from "The Carpal Solution" from which is claimed that it is a patented Medical Technology. I feel they are helpful but alas I cannot do without them as is suggested by the supplier.
Another option I consider is quitting for 4-6 weeks with Letrozole and see if my complaints subside.
Probably you cannot advise me about this but I sure would like to read your opinion about it.

jeremydpbland
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The best known link between drugs for breast cancer and CTS is with exemestane as that one has been quite well documented. It does get a mention here on my site. Letrozole is just another of this group of drugs. All the other hormonal manipulations for breast cancer probably carry similar risks of CTS however. The CTS in these cases seems to respond just as well to treatment as idiopathic CTS and generally the oncologists seem to feel that it is not worth stopping the hormonal treatments because of CTS - so treat it with splints, steroids and surgery just as you would CTS in any other circumstance. Any other treatment sould be considered 'experimental' The carpal solution may be patented but that doesn't mean a lot - it has not been demonstrated to have any useful effect in properly designed randomised trials so that too remains experimental. JB

Albizia
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Dear Dr. Bland, Thank you for your answer. Since then I had my thyroid examined, which was o.k.; stopped 6 weeks with the hormonal treatment, which made no difference; forgot about the Carpal Solution and wore normal splints during the night; did exercises and applied ultrasound during approx. 5 months. Maybe the ultrasound did something because without the splint my left hand is giving me no trouble anymore during the night. Fingers of both hands however start to tingle a/o hurt with activities during daytime and the tip of the middle finger of the RH feels always numb.
May 15th a EMNC test of both hands was made. The results showed clearly that I am suffering from CTS. A Sens.Nerve Conduction test could also be done but whereas it seems to be a rather 'unpleasant' experience I could also skip it. Which I did. The grade of CTS however is not mentioned.
Surgery of the right hand is now planned. Would you please be so kind to give your opinion about the test results? I will send them separately.
Thanking you in advance.

jeremydpbland
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The sensory measurements would probably have been less unpleasant than having the median nerve stimulated at the elbow, which I see they did do. Even without the sensory studies though your median nerve motor conduction is bad enough to make your results bilateral grade 5 CTS, slightly worse in the right hand. For grade 5 surgery is the option most likely to produce a satisfactory result. It's a pity the tests were not done much earlier in the course of the illness as it could probably have saved you a lot of messing about with other treatments which were probably never likely to have much effect. If you've done the basic website diagnostic questionnaire here you could now try out the new prognostic estimate for surgery - there are just a few additional questions to answer and the site will try to give you an estimate of the chances of a good result from the operation. JB

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